International journal of chemical reactor engineering: Effect of magnetic field strength and flow rate on separation distance and recovery rate in a cell-separating microfluidic device

Peermohamed, Shahid Mian; Periyasamy, Muthaimanoj; Lakshminarayanan, Sujatha; Mangadu Natteri, Sudharsan

Effect of magnetic field strength and flow rate on separation distance and recovery rate in a cell-separating microfluidic device / Peermohamed, Shahid Mian (Rights reserved)

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Metadata : Effect of magnetic field strength and flow rate on separation distance and recovery rate in a cell-separating microfluidic device / Peermohamed, Shahid Mian (Rights reserved)

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Eingeschränkter Zugang mit Nutzungsbeschränkungen: Das Dokument ist in den Räumen der Zentral- und Landesbibliothek mit dem "Virtuellen Lesesaal der Landesbibliothek" auf allen Internet-Arbeitsplätzen zugreifbar, darf jedoch nicht kopiert, versendet oder in einem Umfang von mehr als 10% ausgedruckt werden. Weitere Informationen.

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Title:: International journal of chemical reactor engineering

Publication:: Berlin Boston, Mass.: De Gruyter

Note:: Fortsetzung der Druck-Ausgabe; Gesehen am 14.06.23; C!URL-Ä(06-02-12)355!URL-Ä(14-06-23)

Scope:: Online-Ressource

ISSN:: 1542-6580

ZDB-ID:: 2112754-2

VÖBB-Katalog:: 35409864

Keywords:: Zeitschrift

Classification:: Technik

Collection:: Technik

Copyright:: Rights reserved

Accessibility:: Eingeschränkter Zugang mit Nutzungsbeschränkungen

Title:: International journal of chemical reactor engineering

Publication:: Berlin Boston, Mass.: De Gruyter

Note:: Fortsetzung der Druck-Ausgabe; Gesehen am 14.06.23; C!URL-Ä(06-02-12)355!URL-Ä(14-06-23)

Scope:: Online-Ressource

ISSN:: 1542-6580

ZDB-ID:: 2112754-2

VÖBB-Katalog:: 35409864

Keywords:: Zeitschrift

Classification:: Technik

Collection:: Technik

Copyright:: Rights reserved

Accessibility:: Eingeschränkter Zugang mit Nutzungsbeschränkungen

Article

Author:: Peermohamed, Shahid Mian; Periyasamy, Muthaimanoj; Lakshminarayanan, Sujatha; Mangadu Natteri, Sudharsan

Title:: Effect of magnetic field strength and flow rate on separation distance and recovery rate in a cell-separating microfluidic device

Publication:: Berlin Boston, Mass.: De Gruyter, 2025

Language:: English

Information:: Abstract: This study presents a numerical investigation into the effect of magnetic field strength and sheath flow rate on the performance of a magnetophoretic Lab-on-a-Chip (LOC) device for cell separation. Simulations were conducted using a two-dimensional model based on the principle of negative magnetophoresis to achieve label-free separation of particles with diameters of 15.8 and 5.8 µm. The results revealed that separation distance exhibited a non-linear dependence on sheath flow rate for a given magnetic field, with a distinct peak observed at optimal conditions. At a magnetic field strength of 350 mT and a sheath flow rate of 20 μL/min, the device achieved a maximum separation distance of 1.023 mm and a 100 % recovery rate. Furthermore, the separation distance increased at a diminishing rate with rising magnetic field strength and buffer flow rate, following an exponential profile. The optimized LOC design, based on computational fluid dynamics (CFD) simulation, demonstrates that precise control of flow and magnetic parameters can significantly enhance the separation efficiency and recovery rate of microfluidic devices.

Scope:: Online-Ressource

Note:: Kein Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: CFD ; microfluidics ; lab-on-a-chip ; cell-sorting ; magnetophoresis

Classification:: Technik; Wirtschaft

DDC Group:: 330 Wirtschaft

URN:: urn:nbn:de:101:1-2511300350443.963179157449

Collection:: Technik; Wirtschaft

Copyright:: Rights reserved

Accessibility:: Eingeschränkter Zugang mit Nutzungsbeschränkungen

Author:: Peermohamed, Shahid Mian; Periyasamy, Muthaimanoj; Lakshminarayanan, Sujatha; Mangadu Natteri, Sudharsan

Title:: Effect of magnetic field strength and flow rate on separation distance and recovery rate in a cell-separating microfluidic device

Publication:: Berlin Boston, Mass.: De Gruyter, 2025

Language:: English

Information:: Abstract: This study presents a numerical investigation into the effect of magnetic field strength and sheath flow rate on the performance of a magnetophoretic Lab-on-a-Chip (LOC) device for cell separation. Simulations were conducted using a two-dimensional model based on the principle of negative magnetophoresis to achieve label-free separation of particles with diameters of 15.8 and 5.8 µm. The results revealed that separation distance exhibited a non-linear dependence on sheath flow rate for a given magnetic field, with a distinct peak observed at optimal conditions. At a magnetic field strength of 350 mT and a sheath flow rate of 20 μL/min, the device achieved a maximum separation distance of 1.023 mm and a 100 % recovery rate. Furthermore, the separation distance increased at a diminishing rate with rising magnetic field strength and buffer flow rate, following an exponential profile. The optimized LOC design, based on computational fluid dynamics (CFD) simulation, demonstrates that precise control of flow and magnetic parameters can significantly enhance the separation efficiency and recovery rate of microfluidic devices.

Scope:: Online-Ressource

Note:: Kein Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: CFD ; microfluidics ; lab-on-a-chip ; cell-sorting ; magnetophoresis

Classification:: Technik; Wirtschaft

DDC Group:: 330 Wirtschaft

URN:: urn:nbn:de:101:1-2511300350443.963179157449

Collection:: Technik; Wirtschaft

Copyright:: Rights reserved

Accessibility:: Eingeschränkter Zugang mit Nutzungsbeschränkungen

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