- Pfad:
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Evaluation of copeptin in children after stimulation with clonidine or L-Dopa
Dateien
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Zeitschrift
- Titel:
- The journal of pediatric endocrinology and metabolism
- Erschienen:
-
Berlin [u.a.]: de Gruyter
- Umfang:
- Online-Ressource
- ISSN:
- 2191-0251
- ZDB-ID:
-
2583847-7
- VÖBB-Katalog:
- 15261592
- Schlagworte:
- Zeitschrift
- ZLB-Systematik:
- Medizin
- Sammlung:
- Medizin
- Copyright:
- Rechte vorbehalten
- Zugriffsberechtigung:
- Eingeschränkter Zugang mit Nutzungsbeschränkungen
- Titel:
- The journal of pediatric endocrinology and metabolism
- Erschienen:
-
Berlin [u.a.]: de Gruyter
- Umfang:
- Online-Ressource
- ISSN:
- 2191-0251
- ZDB-ID:
-
2583847-7
- VÖBB-Katalog:
- 15261592
- Schlagworte:
- Zeitschrift
- ZLB-Systematik:
- Medizin
- Sammlung:
- Medizin
- Copyright:
- Rechte vorbehalten
- Zugriffsberechtigung:
- Eingeschränkter Zugang mit Nutzungsbeschränkungen
Aufsatz
- Titel:
- Evaluation of copeptin in children after stimulation with clonidine or L-Dopa
- Erschienen:
-
Berlin [u.a.]: de Gruyter, 2024
- Sprache:
- Englisch
- Zusammenfassung:
- Objectives: Arginine-stimulated serum copeptin has been proposed as a new method to diagnose arginine vasopressin (AVP) deficiency in children and adolescents. Herein we investigated the secretagogic potential of clonidine or L-Dopa on the copeptin serum levels in children. Methods: Eight stimulation tests (4 with clonidine and 4 with L-Dopa) were performed in eight children (5 boys and 3 girls) with a median age of 6.5 years-old, evaluated for short stature due to possible growth hormone deficiency. Serum copeptin levels were measured at 30, 60, 90, and 120 min after administration of clonidine or L-Dopa. Results: Copeptin levels in serum did not show any significant change in either test (clonidine or L-Dopa). The values of copeptin levels compared to the baseline value did not deviate more than 5 % in the clonidine arm (p=0.60) or 8 % in the L-Dopa arm (p=0.75) respectively. Conclusions: Data do not support the use of L-Dopa or clonidine as stimulants for evaluating AVP relating disorders in clinical pediatric practice.
- Umfang:
- Online-Ressource
- Fußnote:
- Kein Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Schlagworte:
- copeptin ; vasopressin ; diabetes insipidus ; arginine ; clonidine ; L-Dopa
- Copyright:
- Rechte vorbehalten
- Zugriffsberechtigung:
- Eingeschränkter Zugang mit Nutzungsbeschränkungen
- Titel:
- Evaluation of copeptin in children after stimulation with clonidine or L-Dopa
- Erschienen:
-
Berlin [u.a.]: de Gruyter, 2024
- Sprache:
- Englisch
- Zusammenfassung:
- Objectives: Arginine-stimulated serum copeptin has been proposed as a new method to diagnose arginine vasopressin (AVP) deficiency in children and adolescents. Herein we investigated the secretagogic potential of clonidine or L-Dopa on the copeptin serum levels in children. Methods: Eight stimulation tests (4 with clonidine and 4 with L-Dopa) were performed in eight children (5 boys and 3 girls) with a median age of 6.5 years-old, evaluated for short stature due to possible growth hormone deficiency. Serum copeptin levels were measured at 30, 60, 90, and 120 min after administration of clonidine or L-Dopa. Results: Copeptin levels in serum did not show any significant change in either test (clonidine or L-Dopa). The values of copeptin levels compared to the baseline value did not deviate more than 5 % in the clonidine arm (p=0.60) or 8 % in the L-Dopa arm (p=0.75) respectively. Conclusions: Data do not support the use of L-Dopa or clonidine as stimulants for evaluating AVP relating disorders in clinical pediatric practice.
- Umfang:
- Online-Ressource
- Fußnote:
- Kein Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Schlagworte:
- copeptin ; vasopressin ; diabetes insipidus ; arginine ; clonidine ; L-Dopa
- Copyright:
- Rechte vorbehalten
- Zugriffsberechtigung:
- Eingeschränkter Zugang mit Nutzungsbeschränkungen
