- Path:
-
Interictal plasma urotensin-II concentrations in migraine and tension-type headache: a case–control biomarker study
Files
External resources
Periodical
- Title:
- Journal of laboratory medicine
- Publication:
-
Berlin: De Gruyter
- Note:
- Gesehen am 23.07.2020
- Open Access
- Namensnennung 4.0 International
- 355!URL-Ä.(18-05-20)
- ISSN:
- 2567-9449
- ZDB-ID:
-
2909042-8
- VÖBB-Katalog:
- 35278181
- Previous Title:
- Laboratoriumsmedizin
- Keywords:
- Zeitschrift
- Classification:
- Medizin
- Collection:
- Medizin
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
- Title:
- Journal of laboratory medicine
- Publication:
-
Berlin: De Gruyter
- Note:
- Gesehen am 23.07.2020
- Open Access
- Namensnennung 4.0 International
- 355!URL-Ä.(18-05-20)
- ISSN:
- 2567-9449
- ZDB-ID:
-
2909042-8
- VÖBB-Katalog:
- 35278181
- Previous Title:
- Laboratoriumsmedizin
- Keywords:
- Zeitschrift
- Classification:
- Medizin
- Collection:
- Medizin
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
Article
- Title:
- Interictal plasma urotensin-II concentrations in migraine and tension-type headache: a case–control biomarker study
- Publication:
-
Berlin: De Gruyter, 2026
- Language:
- English
- Information:
- Objectives: As our understanding of the pathophysiology of migraine continues to improve, so too do targeted treatments. It is now known that vasoactive neuropeptides, including calcitonin gene-related peptide (CGRP), play a role in migraine pathophysiology and CGRP antagonists are utilized in treatment. Urotensin II (U-II) represents the most potent vasoconstrictor peptide and research into its association with migraine remains scarce. The current study endeavors to elucidate the biochemical mechanisms which underpin migraine pathophysiology. Methods: The study comprised patients suffering from migraine and tension-type headache alongside a healthy control group. The control group was selected from healthy volunteers of matching gender and age. In the interictal period, plasma samples were collected from patients with migraine and tension-type headache. The study compared plasma U-II levels of 33 migraine patients, 30 tension-type headache patients, and the control group. Results: Plasma U-II levels were significantly higher in the migraine group compared to both the tension-type headache group and the control group. Furthermore, plasma U-II levels were slightly higher in the tension-type headache group than in the control group, however, a statistically significant difference was not observed. Conclusions: These preliminary findings suggest that U-II may be involved in migraine pathophysiology. Higher interictal plasma U-II levels in the migraine group support further investigation of U-II as a possible biomarker candidate. However, given the cross-sectional design and limited sample size, these results should be considered hypothesis-generating and require confirmation in larger prospective studies.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- migraine ; tension-type headache ; pathophysiology ; urotensin II
- Classification:
- Medizin
- Collection:
- Medizin
- Copyright:
- CC BY
- Accessibility:
- Free Access
- Title:
- Interictal plasma urotensin-II concentrations in migraine and tension-type headache: a case–control biomarker study
- Publication:
-
Berlin: De Gruyter, 2026
- Language:
- English
- Information:
- Objectives: As our understanding of the pathophysiology of migraine continues to improve, so too do targeted treatments. It is now known that vasoactive neuropeptides, including calcitonin gene-related peptide (CGRP), play a role in migraine pathophysiology and CGRP antagonists are utilized in treatment. Urotensin II (U-II) represents the most potent vasoconstrictor peptide and research into its association with migraine remains scarce. The current study endeavors to elucidate the biochemical mechanisms which underpin migraine pathophysiology. Methods: The study comprised patients suffering from migraine and tension-type headache alongside a healthy control group. The control group was selected from healthy volunteers of matching gender and age. In the interictal period, plasma samples were collected from patients with migraine and tension-type headache. The study compared plasma U-II levels of 33 migraine patients, 30 tension-type headache patients, and the control group. Results: Plasma U-II levels were significantly higher in the migraine group compared to both the tension-type headache group and the control group. Furthermore, plasma U-II levels were slightly higher in the tension-type headache group than in the control group, however, a statistically significant difference was not observed. Conclusions: These preliminary findings suggest that U-II may be involved in migraine pathophysiology. Higher interictal plasma U-II levels in the migraine group support further investigation of U-II as a possible biomarker candidate. However, given the cross-sectional design and limited sample size, these results should be considered hypothesis-generating and require confirmation in larger prospective studies.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- migraine ; tension-type headache ; pathophysiology ; urotensin II
- Classification:
- Medizin
- Collection:
- Medizin
- Copyright:
- CC BY
- Accessibility:
- Free Access
