- Path:
-
An HPLC–HRMS profiling of dietary supplements declaring andarine (S-4)
Files
External resources
Periodical
- Title:
- Reviews in analytical chemistry
- Publication:
-
Berlin: de Gruyter
- Note:
- Gesehen am 30.08.2021
- Open Access
- Namensnennung 4.0 International
- Scope:
- Online-Ressource
- ISSN:
- 2191-0189
- ZDB-ID:
-
2602435-4
- VÖBB-Katalog:
- 15605269
- Keywords:
- Zeitschrift
- Classification:
- Naturwissenschaften
- Collection:
- Naturwissenschaften
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
- Title:
- Reviews in analytical chemistry
- Publication:
-
Berlin: de Gruyter
- Note:
- Gesehen am 30.08.2021
- Open Access
- Namensnennung 4.0 International
- Scope:
- Online-Ressource
- ISSN:
- 2191-0189
- ZDB-ID:
-
2602435-4
- VÖBB-Katalog:
- 15605269
- Keywords:
- Zeitschrift
- Classification:
- Naturwissenschaften
- Collection:
- Naturwissenschaften
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
Article
- Title:
- An HPLC–HRMS profiling of dietary supplements declaring andarine (S-4)
- Publication:
-
Berlin: de Gruyter, 2026
- Language:
- English
- Information:
- Abstract: Selective androgen receptor modulators (SARMs), including andarine (S-4), have gained significant attention in the dietary supplement market despite their known health risks and prohibition in competitive sports. Although andarine remains widely available, data on its actual presence in dietary supplements are limited. To address this gap, this study assessed the quality of dietary supplements marketed as containing andarine. An HPLC–HRMS method was developed, validated, and applied to analyze three commercially available dietary supplements. HRMS (QTOF) detection, in MS as well as MS/MS regimes, was essential for confirming the presence of andarine and unexpectedly identifying other biologically active substances, specifically the metabolic modulators SR9009 and GW501516, based on precise molecular weights of precursor and product ions relative to reference standards. The analysis revealed discrepancies between the labeled and actual contents of the analyzed dietary supplements. These findings underscore the potential health risks posed by mislabeled and adulterated dietary supplements and highlight the urgent need for stricter quality control and regulatory oversight in the dietary supplement industry.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- HPLC–HRMS ; dietary supplements ; SARMs ; andarine ; SR9009 ; GW501516
- Classification:
- Naturwissenschaften
- Recht
- DDC Group:
- 340 Recht
- Collection:
- Naturwissenschaften
- Recht
- Copyright:
- CC BY
- Accessibility:
- Free Access
- Title:
- An HPLC–HRMS profiling of dietary supplements declaring andarine (S-4)
- Publication:
-
Berlin: de Gruyter, 2026
- Language:
- English
- Information:
- Abstract: Selective androgen receptor modulators (SARMs), including andarine (S-4), have gained significant attention in the dietary supplement market despite their known health risks and prohibition in competitive sports. Although andarine remains widely available, data on its actual presence in dietary supplements are limited. To address this gap, this study assessed the quality of dietary supplements marketed as containing andarine. An HPLC–HRMS method was developed, validated, and applied to analyze three commercially available dietary supplements. HRMS (QTOF) detection, in MS as well as MS/MS regimes, was essential for confirming the presence of andarine and unexpectedly identifying other biologically active substances, specifically the metabolic modulators SR9009 and GW501516, based on precise molecular weights of precursor and product ions relative to reference standards. The analysis revealed discrepancies between the labeled and actual contents of the analyzed dietary supplements. These findings underscore the potential health risks posed by mislabeled and adulterated dietary supplements and highlight the urgent need for stricter quality control and regulatory oversight in the dietary supplement industry.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- HPLC–HRMS ; dietary supplements ; SARMs ; andarine ; SR9009 ; GW501516
- Classification:
- Naturwissenschaften
- Recht
- DDC Group:
- 340 Recht
- Collection:
- Naturwissenschaften
- Recht
- Copyright:
- CC BY
- Accessibility:
- Free Access
