- Path:
-
Volume Nr. 3, 9. Januar 1923
Periodical
- Title:
- Pleura and peritoneum
- Publication:
-
Berlin Boston: de Gruyter
- Note:
- Gesehen am 24.01.2023
- Open Access
- Namensnennung 4.0 International
- Archivierung/Langzeitarchivierung gewährleistet
- C!URL-Ä(24-08-18)
- Scope:
- Online-Ressource
- ISSN:
- 2364-768X
- ZDB-ID:
-
2861909-2
- VÖBB-Katalog:
- 35425659
- Keywords:
- Zeitschrift
- Classification:
- Medizin
- Collection:
- Medizin
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
Article
- Title:
- Extent of peritoneal metastases from colorectal cancer is not associated with changes in thrombin generation or fibrinolysis
- Publication:
-
Berlin Boston: de Gruyter, 2024
- Language:
- English
- Information:
- Objectives: Cancer cells can activate coagulation and inhibit fibrinolysis. The aim was to investigate the association between the burden of peritoneal metastases from colorectal cancer (PM-CRC) and biomarkers reflecting thrombin generation and fibrinolysis. Methods: A cohort of 55 patients with PM-CRC scheduled for cytoreductive surgery. Patients were grouped by the peritoneal cancer index (PCI) assessed intraoperatively into limited PM-CRC (PCI≤15) and extensive PM-CRC (PCI>15). Blood samples were obtained before surgery. Thrombin generation was measured in vivo by thrombin-antithrombin complex (TAT) and prothrombin fragment 1+2 (F1+2), and ex vivo by the endogenous thrombin potential (ETP). Fibrinolysis was analyzed with fibrin clot lysis assay, fibrinogen, and D-dimer. Results: Non-significantly decreased thrombin generation by F1+2 (p=0.72), TAT (p=0.32), and ETP (p=0.19) were observed in patients with extensive PM-CRC (n=9) compared with limited PM-CRC (n=46). Non-significantly prolonged 50 % clot lysis time were found in patients with extensive PM-CRC than in patients with limited PM-CRC. Conclusions: Minor non-significant differences in thrombin generation and fibrinolysis were found between patients with extensive PM-CRC and limited PM-CRC. Thus, increased peritoneal metastatic burden from colorectal cancer does not seem to affect thrombin generation and fibrinolysis.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- colorectal cancer ; metastases ; blood coagulation ; embolisms and thrombosis ; cytoreductive surgery
- Copyright:
- CC BY
- Accessibility:
- Free Access
