Open medicine: Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26

Yang, Yanyan; Wu, Shiwen; Lin, Minghao; Xie, Xueting; Shi, Huifang; Chen, Youran; Li, Shanshan; Jiang, Yuchun; Zheng, Sijie; Shen, Chibin; Yang, Naibin; Lu, Mingqin

Creator: Yang, Yanyan Wu, Shiwen Lin, Minghao Xie, Xueting Shi, Huifang Chen, Youran Li, Shanshan Jiang, Yuchun Zheng, Sijie Shen, Chibin Yang, Naibin Lu, Mingqin Publication: Berlin: de Gruyter, 2025
URN: urn:nbn:de:101:1-2509040610153.075775857132

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Turkish journal of biochemistry

Periodical

Title:: Turkish journal of biochemistry

Parallelsachtitel:: Türk biyokimya dergisi

Publication:: Berlin: de Gruyter

Note:: Gesehen am 31.08.22

Scope:: Online-Ressource

ISSN:: 1303-829X

ZDB-ID:: 2244112-8

VÖBB-Katalog:: 35314094

Keywords:: Zeitschrift

Classification:: Naturwissenschaften

Collection:: Naturwissenschaften

Copyright:: Rights reserved

Accessibility:: Eingeschränkter Zugang mit Nutzungsbeschränkungen

Impact of calcium propionate on cellular behavior in A549 and DMS114 lung cancer cell lines

Article

Author:: Okyay, Tugba Muhlise; Güler, Eray Metin; Kale, Ebru; Gultekin, Fatih; Koldas, Macit

Title:: Impact of calcium propionate on cellular behavior in A549 and DMS114 lung cancer cell lines

Publication:: Berlin: de Gruyter, 2024

Language:: English

Information:: Objectives: To investigate the cellular and apoptotic effects of food additive calcium propionate by in vitro methods. Methods: Cell viability by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, intracellular Glutathione (GSH) by luminometric method, mitochondrial membrane potential (MMP) by fluorometry, apoptosis by dual Acridine Orange/Ethidium Bromide (AO/EB) fluorescent staining were studied in lung cells. Results: It has been observed that calcium propionate reduced GSH and MMP levels significantly while increased cytotoxicity, apoptosis, and reactive oxygen species (ROS) levels in both A549 and DMS114 cancer cells in a dose-dependent manner. Conclusions: Cytotoxic effects of calcium propionate were more pronounced in cancer cells compared to healthy cells, suggesting its potential suitability as a chemo-preventive agent.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: calcium propionate ; cancer ; food additive ; cell viability ; lung cancer

Classification:: Naturwissenschaften; Sonstiges

URN:: urn:nbn:de:101:1-2410241537200.324704492556

Collection:: Naturwissenschaften; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Endotoxin tolerance inhibits NLRP3 inflammasome activation in macrophages of septic mice by restoring autophagic flux through TRIM26 / Yang, Yanyan (CC BY)