- Pfad:
Zeitschrift
- Titel:
- Biomedical engineering
- Parallelsachtitel:
- Biomedizinische Technik
- Erschienen:
-
Berlin [u.a.]: de Gruyter
- Fußnote:
- Gesehen am 09.08.2017
- 82+7!(26-08-11)355!URL-Ä(09-08-17)
- ISSN:
- 1862-278X
- ZDB-ID:
-
2234381-7
- VÖBB-Katalog:
- 15139245
- Frühere Titel:
- Elektromedizin, Biomedizin und Technik
- Schlagworte:
- Biomedizinische Technik ; Zeitschrift
- ZLB-Systematik:
- Medizin
- Sammlung:
- Medizin
- Copyright:
- Rechte vorbehalten
- Zugriffsberechtigung:
- Eingeschränkter Zugang mit Nutzungsbeschränkungen
Aufsatz
- Titel:
- Effect of calcium phosphate/bovine serum albumin coated Al 2 O 3 –Ti biocomposites on osteoblast response
- Erschienen:
-
Berlin [u.a.]: de Gruyter, 2024
- Sprache:
- Englisch
- Zusammenfassung:
- Objectives: The biological performance of aluminum oxide-titanium (Al2O3-Ti) composites requires special attention to achieve improved osteoblastic differentiation, and subsequent osseointegration/strong anchorage with the surrounding bone. Therefore, the aim of this study was to improve them by providing calcium phosphate (Ca-P)/bovine serum albumin (BSA) coating on their surfaces. Methods: Ca-P/BSA coatings were prepared on the surfaces of 75vol.%Ti composites (75Ti-BSA) and pure Ti (100Ti-BSA as a control). The surface characteristics, phase analysis, micro-hardness, BSA release profile and biological responses including cytotoxicity, cell viability, differentiation, mineralization, and cell adhesion were evaluated. Results: The results showed that lower cytotoxicity% and higher mitochondrial activity or viability % were associated with the samples with Ca-P/BSA coatings (particularly 75Ti-BSA having 21.3% cytotoxicity, 111.4% and 288.6% viability at day 1 and 7, respectively). Furthermore, the Ca-P/BSA coating could highly enhance the differentiation of pre-osteoblast cells into osteoblasts in 75Ti-BSA group (ALP concentration of 4.8 ng/ml). However, its influence on cell differentiation in 100Ti-BSA group was negligible. Similar results were also obtained from mineralization assay. The results on cell adhesion revealed that the Ca-P/BSA coated samples differently interacted with MC3T3-E1 cells; enlarged flat cells on 75Ti-BSA vs more spindle-shaped cells on 100Ti-BSA. Conclusions: Ca-P/BSA coated Al2O3-Ti provided promising biological performance, superior to that of uncoated composites. Therefore, they have the potential to improve implant osseointegration.
- Umfang:
- Online-Ressource
- Fußnote:
- Kein Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Schlagworte:
- osteoblast ; composite ; bovine serum albumin ; hydroxyapatite ; biocompatibility ; mineralization
- ZLB-Systematik:
- Medizin
- Sammlung:
- Medizin
- Copyright:
- Rechte vorbehalten
- Zugriffsberechtigung:
- Eingeschränkter Zugang mit Nutzungsbeschränkungen
