- Path:
-
Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous
Files
External resources
Periodical
- Title:
- Open life sciences
- Publication:
-
Berlin: De Gruyter
- Note:
- Gesehen am 15.04.15
- Open Access
- Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
- Scope:
- Online-Ressource
- ISSN:
- 2391-5412
- ZDB-ID:
-
2817958-4
- Keywords:
- Zeitschrift
- Classification:
- Naturwissenschaften
- DDC Group:
- 570 Biowissenschaften, Biologie
- Collection:
- Naturwissenschaften
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
- Title:
- Open life sciences
- Publication:
-
Berlin: De Gruyter
- Note:
- Gesehen am 15.04.15
- Open Access
- Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International
- Scope:
- Online-Ressource
- ISSN:
- 2391-5412
- ZDB-ID:
-
2817958-4
- Keywords:
- Zeitschrift
- Classification:
- Naturwissenschaften
- DDC Group:
- 570 Biowissenschaften, Biologie
- Collection:
- Naturwissenschaften
- Copyright:
- Rights reserved
- Accessibility:
- Free Access
Article
- Title:
- Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous
- Publication:
-
Berlin: De Gruyter, 2024
- Language:
- English
- Information:
- Abstract: Henoch-Schönlein purpura (HSP) and pediatric-onset systemic lupus erythematosus (pSLE) are closely associated with vasculitis and vascular diseases. This study aimed to investigate the clinical diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE. We surveyed 82 HSP patients, 34 pSLE patients, and 10 healthy children. The expression levels of Ang-1, Ang-2, and Tie2 in the serum and urine were assessed using enzyme-linked immunosorbent assay. The diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE were evaluated using receiver operating characteristic curve analysis. The results revealed that the serum and urine expression levels of Ang-2 and Tie2 were significantly elevated in HSP and pSLE patients, whereas the Ang-1/Ang-2 values were reduced. Additionally, Ang-1 was highly expressed in the serum and urine of HSP patients and in the serum of pSLE patients. Ang-1, Ang-2, and Tie2 showed differential expression in various types of HSP and pSLE compared with their expression in healthy controls. In summary, Ang-1, Ang-2, and Tie2 can serve as biomarkers for HSP and pSLE. Moreover, Ang-1/Ang-2 values are reduced in HSP and pSLE patients. Ang-1, Ang-2, and Tie2 can be used as biomarkers for HSP and pSLE.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- Henoch-Schönlein purpura ; systemic lupus erythematous ; angiopoietins ; Tie2 immunoglobulin A vasculitis ; autoimmune diseases
- Classification:
- Naturwissenschaften
- Sonstiges
- Collection:
- Naturwissenschaften
- Sonstiges
- Copyright:
- CC BY
- Accessibility:
- Free Access
- Title:
- Ang-1, Ang-2, and Tie2 are diagnostic biomarkers for Henoch-Schönlein purpura and pediatric-onset systemic lupus erythematous
- Publication:
-
Berlin: De Gruyter, 2024
- Language:
- English
- Information:
- Abstract: Henoch-Schönlein purpura (HSP) and pediatric-onset systemic lupus erythematosus (pSLE) are closely associated with vasculitis and vascular diseases. This study aimed to investigate the clinical diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE. We surveyed 82 HSP patients, 34 pSLE patients, and 10 healthy children. The expression levels of Ang-1, Ang-2, and Tie2 in the serum and urine were assessed using enzyme-linked immunosorbent assay. The diagnostic values of Ang-1, Ang-2, and Tie2 for HSP and pSLE were evaluated using receiver operating characteristic curve analysis. The results revealed that the serum and urine expression levels of Ang-2 and Tie2 were significantly elevated in HSP and pSLE patients, whereas the Ang-1/Ang-2 values were reduced. Additionally, Ang-1 was highly expressed in the serum and urine of HSP patients and in the serum of pSLE patients. Ang-1, Ang-2, and Tie2 showed differential expression in various types of HSP and pSLE compared with their expression in healthy controls. In summary, Ang-1, Ang-2, and Tie2 can serve as biomarkers for HSP and pSLE. Moreover, Ang-1/Ang-2 values are reduced in HSP and pSLE patients. Ang-1, Ang-2, and Tie2 can be used as biomarkers for HSP and pSLE.
- Scope:
- Online-Ressource
- Note:
- Open Access
- Archivierung/Langzeitarchivierung gewährleistet
- Keywords:
- Henoch-Schönlein purpura ; systemic lupus erythematous ; angiopoietins ; Tie2 immunoglobulin A vasculitis ; autoimmune diseases
- Classification:
- Naturwissenschaften
- Sonstiges
- Collection:
- Naturwissenschaften
- Sonstiges
- Copyright:
- CC BY
- Accessibility:
- Free Access
