Open chemistry: 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies

Arif, Mehreen; Ur Rehman, Naeem; Anjum, Irfan; Rauf, Khalid; Alotaibi, Amal; Alhmidani, Ghala

6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies / Arif, Mehreen (CC BY)

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fullscreen : 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies / Arif, Mehreen (CC BY)

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CC BY: Attribution 4.0 International. You can find more information here.

Periodical

Title:: Open chemistry

Publication:: Berlin: de Gruyter

Note:: Gesehen am 23.06.15; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2391-5420

ZDB-ID:: 2825411-9

VÖBB-Katalog:: 35314079

Previous Title:: Central European journal of chemistry

Keywords:: Zeitschrift

Classification:: Naturwissenschaften

Collection:: Naturwissenschaften

Copyright:: Rights reserved

Accessibility:: Free Access

Title:: Open chemistry

Publication:: Berlin: de Gruyter

Note:: Gesehen am 23.06.15; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2391-5420

ZDB-ID:: 2825411-9

VÖBB-Katalog:: 35314079

Previous Title:: Central European journal of chemistry

Keywords:: Zeitschrift

Classification:: Naturwissenschaften

Collection:: Naturwissenschaften

Copyright:: Rights reserved

Accessibility:: Free Access

Article

Author:: Arif, Mehreen; Ur Rehman, Naeem; Anjum, Irfan; Rauf, Khalid; Alotaibi, Amal; Alhmidani, Ghala

Title:: 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies

Publication:: Berlin: de Gruyter, 2024

Language:: English

Information:: Abstract: 6-Methoxyflavone (6-MOF) is a flavonoid that has been reported to be a GABA-A receptor agonist and reverses cisplatin-induced hyperalgesia and allodynia. Considering the varied neuropharmacological profile of 6-MOF, this study was intended to determine the pharmacological effects of 6-MOF on locomotion, anxiety, novel object recognition (NOR), depression, spatial memory, socialization behavior, nest-building behavior, and depression in various groups of mice. Selected groups of mice were injected with 25, 50, and 75 mg/kg 6-MOF. Using HPLC-UV, the frontal cortex, striatum, and hippocampus of the sacrificed mice were analyzed for the levels of vitamin C, dopamine, serotonin, noradrenaline, adenosine, and its metabolites. Statistical analysis showed significant results in socialization behavior and elevated plus maze with 75 mg/kg. In Y-maze, NOR 6-MOF showed significant results at all three doses, while in tail suspension test (TST), 50 and 75 mg/kg showed significant results; however, no statistical significance was observed in nest-building behavior; 50 and 75 mg/kg 6-MOF showed significant results in the Morris water maze. 6-MOF raised vitamin C levels in the frontal cortex and hippocampus. Serotonin, dopamine, and nor-adrenaline levels were raised in the hippocampus and striatum. It has also imparted region-specific neuroprotection by improving adenosine and its metabolite levels. In silico studies performed using PyRx have shown that the minimum binding energy of 6-MOF with antioxidant enzyme is −7.1 k/cal/mol. The binding energy showed that 6-MOF was successfully docked with an anti-oxidant enzyme. In conclusion, in silico and behavioral studies showed that 6-MOF can be a potential candidate for the treatment of cognitive decline, anxiety, and depression.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: serotonin ; dopamine ; noradrenaline ; 6-methoxyflavone ; adenosine

Classification:: Naturwissenschaften; Sonstiges

URN:: urn:nbn:de:101:1-2410261535214.298236181298

Collection:: Naturwissenschaften; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Author:: Arif, Mehreen; Ur Rehman, Naeem; Anjum, Irfan; Rauf, Khalid; Alotaibi, Amal; Alhmidani, Ghala

Title:: 6-Methoxyflavone improves anxiety, depression, and memory by increasing monoamines in mice brain: HPLC analysis and in silico studies

Publication:: Berlin: de Gruyter, 2024

Language:: English

Information:: Abstract: 6-Methoxyflavone (6-MOF) is a flavonoid that has been reported to be a GABA-A receptor agonist and reverses cisplatin-induced hyperalgesia and allodynia. Considering the varied neuropharmacological profile of 6-MOF, this study was intended to determine the pharmacological effects of 6-MOF on locomotion, anxiety, novel object recognition (NOR), depression, spatial memory, socialization behavior, nest-building behavior, and depression in various groups of mice. Selected groups of mice were injected with 25, 50, and 75 mg/kg 6-MOF. Using HPLC-UV, the frontal cortex, striatum, and hippocampus of the sacrificed mice were analyzed for the levels of vitamin C, dopamine, serotonin, noradrenaline, adenosine, and its metabolites. Statistical analysis showed significant results in socialization behavior and elevated plus maze with 75 mg/kg. In Y-maze, NOR 6-MOF showed significant results at all three doses, while in tail suspension test (TST), 50 and 75 mg/kg showed significant results; however, no statistical significance was observed in nest-building behavior; 50 and 75 mg/kg 6-MOF showed significant results in the Morris water maze. 6-MOF raised vitamin C levels in the frontal cortex and hippocampus. Serotonin, dopamine, and nor-adrenaline levels were raised in the hippocampus and striatum. It has also imparted region-specific neuroprotection by improving adenosine and its metabolite levels. In silico studies performed using PyRx have shown that the minimum binding energy of 6-MOF with antioxidant enzyme is −7.1 k/cal/mol. The binding energy showed that 6-MOF was successfully docked with an anti-oxidant enzyme. In conclusion, in silico and behavioral studies showed that 6-MOF can be a potential candidate for the treatment of cognitive decline, anxiety, and depression.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: serotonin ; dopamine ; noradrenaline ; 6-methoxyflavone ; adenosine

Classification:: Naturwissenschaften; Sonstiges

URN:: urn:nbn:de:101:1-2410261535214.298236181298

Collection:: Naturwissenschaften; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

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