NeuroImmune Pharmacology and Therapeutics: Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis

Mady, Abdelrahman; Kashbour, Muataz; Abu-Qare’e, Omar; Jaffal, Rana; Khaled, Ahmed; Daoud, Asma; Samir, Mahmoud; Belakhdar, Abdelbassat; Awwad, Sara Adel; Mansour, Hend; Ayad, Qusai; Elashwah, Hamza; Fathi, Nihal; Barrett, Matthew J.; Negida, Ahmed

Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis / Mady, Abdelrahman (CC BY)

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Full text : Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis / Mady, Abdelrahman (CC BY)

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Periodical

Title:: NeuroImmune Pharmacology and Therapeutics

Publication:: Berlin: De Gruyter

Note:: Gesehen am 3. Juni 2022; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2750-6665

ZDB-ID:: 3107864-3

VÖBB-Katalog:: 35283945

Keywords:: Zeitschrift

Classification:: Medizin

Collection:: Medizin

Copyright:: Rights reserved

Accessibility:: Free Access

Title:: NeuroImmune Pharmacology and Therapeutics

Publication:: Berlin: De Gruyter

Note:: Gesehen am 3. Juni 2022; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2750-6665

ZDB-ID:: 3107864-3

VÖBB-Katalog:: 35283945

Keywords:: Zeitschrift

Classification:: Medizin

Collection:: Medizin

Copyright:: Rights reserved

Accessibility:: Free Access

Article

Author:: Mady, Abdelrahman; Kashbour, Muataz; Abu-Qare’e, Omar; Jaffal, Rana; Khaled, Ahmed; Daoud, Asma; Samir, Mahmoud; Belakhdar, Abdelbassat; Awwad, Sara Adel; Mansour, Hend; Ayad, Qusai; Elashwah, Hamza; Fathi, Nihal; Barrett, Matthew J.; Negida, Ahmed

Title:: Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis

Publication:: Berlin: De Gruyter, 2025

Language:: English

Information:: Introduction: Several observational studies reported an association between Rheumatoid Arthritis (RA) and the subsequent risk of developing Parkinson’s disease (PD). However, whether the drugs commonly prescribed for RA contribute to this association remains controversial. Content: We sought to summarize all the published evidence regarding the association between the drugs used for RA and the risk of developing PD as well as to explore the potential neuroprotective and therapeutic potential of these drugs for PD patients. We searched three electronic biomedical databases (namely, PubMed, Scopus, and Web of Science) to find potentially relevant studies. The outcome of interest was the relative risk (RR) of developing PD in individuals taking any of these drugs: (1) non-steroidal anti-inflammatory drugs (NSAIDs), (2) acetaminophen, (3) corticosteroids, and (4) disease-modifying anti-rheumatoid drugs (DMARDs), compared to individuals not taking them. Summary and outlook: 26 studies (15 case-control and 11 cohort) were included in the analysis with a total number of 4,321,104 participants including 150,703 PD cases. Analysis showed a statistically significant lower risk of developing PD among individuals who received corticosteroids (RR 0.80, 95% CI 0.77 – 0.84, P<0.00001) and DMARDs (RR 0.69, 95% CI 0.55 – 0.86, P<0.001). Subgroup analysis by individual drugs showed a decreased risk with dexamethasone (RR 0.69, 95% CI 0.60 – 0.79, P<0.00001) and hydroxychloroquine (RR 0.77, 95% CI 0.66 – 0.90, P<0.001). Our findings showed that individuals who were treated with corticosteroids (especially dexamethasone) and DMARDs (especially hydroxychloroquine) have reduced risk of developing PD compared to those not receiving these medications.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Parkinson’s disease ; rheumatoid arthritis ; meta-analysis

Classification:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2505040655595.090839081893

Collection:: Medizin; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Author:: Mady, Abdelrahman; Kashbour, Muataz; Abu-Qare’e, Omar; Jaffal, Rana; Khaled, Ahmed; Daoud, Asma; Samir, Mahmoud; Belakhdar, Abdelbassat; Awwad, Sara Adel; Mansour, Hend; Ayad, Qusai; Elashwah, Hamza; Fathi, Nihal; Barrett, Matthew J.; Negida, Ahmed

Title:: Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis

Publication:: Berlin: De Gruyter, 2025

Language:: English

Information:: Introduction: Several observational studies reported an association between Rheumatoid Arthritis (RA) and the subsequent risk of developing Parkinson’s disease (PD). However, whether the drugs commonly prescribed for RA contribute to this association remains controversial. Content: We sought to summarize all the published evidence regarding the association between the drugs used for RA and the risk of developing PD as well as to explore the potential neuroprotective and therapeutic potential of these drugs for PD patients. We searched three electronic biomedical databases (namely, PubMed, Scopus, and Web of Science) to find potentially relevant studies. The outcome of interest was the relative risk (RR) of developing PD in individuals taking any of these drugs: (1) non-steroidal anti-inflammatory drugs (NSAIDs), (2) acetaminophen, (3) corticosteroids, and (4) disease-modifying anti-rheumatoid drugs (DMARDs), compared to individuals not taking them. Summary and outlook: 26 studies (15 case-control and 11 cohort) were included in the analysis with a total number of 4,321,104 participants including 150,703 PD cases. Analysis showed a statistically significant lower risk of developing PD among individuals who received corticosteroids (RR 0.80, 95% CI 0.77 – 0.84, P<0.00001) and DMARDs (RR 0.69, 95% CI 0.55 – 0.86, P<0.001). Subgroup analysis by individual drugs showed a decreased risk with dexamethasone (RR 0.69, 95% CI 0.60 – 0.79, P<0.00001) and hydroxychloroquine (RR 0.77, 95% CI 0.66 – 0.90, P<0.001). Our findings showed that individuals who were treated with corticosteroids (especially dexamethasone) and DMARDs (especially hydroxychloroquine) have reduced risk of developing PD compared to those not receiving these medications.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Parkinson’s disease ; rheumatoid arthritis ; meta-analysis

Classification:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2505040655595.090839081893

Collection:: Medizin; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Full text : Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis / Mady, Abdelrahman (CC BY)

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Full text : Rheumatoid arthritis drugs and the risk of Parkinson’s disease – a meta-analysis / Mady, Abdelrahman (CC BY)

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CC BY: Attribution 4.0 International. You can find more information here.