Medical Review: Emerging magic bullet: subcellular organelle-targeted cancer therapy

Yan, Yue; Zhang, Yimeng; Liu, Jianxiong; Chen, Binlong; Wang, Yiguang

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Title:: Medical Review

Publication:: Berlin: De Gruyter

Note:: Gesehen am 23.10.23; Open Access; Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International

Scope:: Online-Ressource

ISSN:: 2749-9642

ZDB-ID:: 3097614-5

VÖBB-Katalog:: 35283921

Keywords:: Zeitschrift

Classification:: Medizin

Collection:: Medizin

Copyright:: Rights reserved

Accessibility:: Free Access

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Author:: Yan, Yue; Zhang, Yimeng; Liu, Jianxiong; Chen, Binlong; Wang, Yiguang

Title:: Emerging magic bullet: subcellular organelle-targeted cancer therapy

Publication:: Berlin: De Gruyter, 2025

Language:: English

Information:: Abstract: The therapeutic efficacy of anticancer drugs heavily relies on their concentration and retention at the corresponding target site. Hence, merely increasing the cellular concentration of drugs is insufficient to achieve satisfactory therapeutic outcomes, especially for the drugs that target specific intracellular sites. This necessitates the implementation of more precise targeting strategies to overcome the limitations posed by diffusion distribution and nonspecific interactions within cells. Consequently, subcellular organelle-targeted cancer therapy, characterized by its exceptional precision, have emerged as a promising approach to eradicate cancer cells through the specific disruption of subcellular organelles. Owing to several advantages including minimized dosage and side effect, optimized efficacy, and reversal of multidrug resistance, subcellular organelle-targeted therapies have garnered significant research interest in recent years. In this review, we comprehensively summarize the distribution of drug targets, targeted delivery strategies at various levels, and sophisticated strategies for targeting specific subcellular organelles. Additionally, we highlight the significance of subcellular targeting in cancer therapy and present essential considerations for its clinical translation.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: cancer ; drug targets ; subcellular targeting ; drug delivery ; organelle

Classification:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2504150636056.195247137121

Collection:: Medizin; Sonstiges

Copyright:: Rights reserved

Accessibility:: Free Access

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fullscreen: Emerging magic bullet: subcellular organelle-targeted cancer therapy / Yan, Yue (Rights reserved) Access restriction There is no access restriction for this record. Copyright No licence for use has been granted - all rights reserved.

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fullscreen: Emerging magic bullet: subcellular organelle-targeted cancer therapy / Yan, Yue (Rights reserved)

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