Innovative surgical sciences: Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study

Kandukuri, Jayanth; Jain, Aseem; Karmarkar, Parag; Gadagkar, Hrishikesh; Aberman, Harold; Wang, Qihong; Rege, Abhishek

Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study / Kandukuri, Jayanth (CC BY)

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Metadaten : Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study / Kandukuri, Jayanth (CC BY)

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Titel:: Innovative surgical sciences

Erschienen:: Berlin: de Gruyter

Fußnote:: Open Access; Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International

Umfang:: Online-Ressource

ISSN:: 2364-7485

ZDB-ID:: 2876075-X

VÖBB-Katalog:: 35278161

Schlagworte:: Zeitschrift

ZLB-Systematik:: Medizin

Sammlung:: Medizin

Copyright:: Rechte vorbehalten

Zugriffsberechtigung:: Freier Zugang

Titel:: Innovative surgical sciences

Erschienen:: Berlin: de Gruyter

Fußnote:: Open Access; Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International

Umfang:: Online-Ressource

ISSN:: 2364-7485

ZDB-ID:: 2876075-X

VÖBB-Katalog:: 35278161

Schlagworte:: Zeitschrift

ZLB-Systematik:: Medizin

Sammlung:: Medizin

Copyright:: Rechte vorbehalten

Zugriffsberechtigung:: Freier Zugang

Aufsatz

Verfasser:: Kandukuri, Jayanth; Jain, Aseem; Karmarkar, Parag; Gadagkar, Hrishikesh; Aberman, Harold; Wang, Qihong; Rege, Abhishek

Titel:: Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study

Erschienen:: Berlin: de Gruyter, 2024

Sprache:: Englisch

Zusammenfassung:: Objectives: Intraoperative monitoring of blood flow (BF) remains vital to guiding surgical decisions. Here, we report the use of SurgeON™ Blood Flow Monitor (BFM), a prototype system that attaches to surgical microscopes and implements laser speckle contrast imaging (LSCI) to noninvasively obtain and present vascular BF information in real-time within the microscope’s eyepiece. Methods: The ability of SurgeON BFM to monitor BF status during reversible vascular occlusion procedures was investigated in two large animal models: occlusion of saphenous veins in six NZW rabbit hindlimbs and clipping of middle cerebral artery (MCA) branches in four Dorset sheep brain hemispheres. SurgeON BFM acquired, presented, and stored LSCI-based blood flow velocity index (BFVi) data and performed indocyanine green video angiography (ICG-VA) for corroboration. Results: Stored BFVi data were analyzed for each phase: pre-occlusion (baseline), with the vessel occluded (occlusion), and after reversal of occlusion (re-perfusion). In saphenous veins, BFVi relative to baseline reduced to 5.2±3.7 % during occlusion and returned to 102.9±14.9 % during re-perfusion. Unlike ICG-VA, SurgeON BFM was able to monitor reduced BFVi and characterize re-perfusion robustly during five serial occlusion procedures conducted 2–5 min apart on the same vessel. Across four sheep MCA vessels, BFVi reduced to 18.6±7.7 % and returned to 120.1±27.8 % of baseline during occlusion and re-perfusion phases, respectively. Conclusions: SurgeON BFM can noninvasively monitor vascular occlusion status and provide intuitive visualization of BF information in real-time to an operating surgeon. This technology may find application in vascular, plastic, and neurovascular surgery.

Umfang:: Online-Ressource

Fußnote:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Schlagworte:: blood flow imaging ; real-time feedback ; surgical technology ; noninvasive monitoring ; augmented reality visualization

ZLB-Systematik:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2405311537563.957208497356

Sammlung:: Medizin; Sonstiges

Copyright:: CC BY

Zugriffsberechtigung:: Freier Zugang

Verfasser:: Kandukuri, Jayanth; Jain, Aseem; Karmarkar, Parag; Gadagkar, Hrishikesh; Aberman, Harold; Wang, Qihong; Rege, Abhishek

Titel:: Realtime assessment of vascular occlusion and reperfusion in animal models of intraoperative imaging – a pilot study

Erschienen:: Berlin: de Gruyter, 2024

Sprache:: Englisch

Zusammenfassung:: Objectives: Intraoperative monitoring of blood flow (BF) remains vital to guiding surgical decisions. Here, we report the use of SurgeON™ Blood Flow Monitor (BFM), a prototype system that attaches to surgical microscopes and implements laser speckle contrast imaging (LSCI) to noninvasively obtain and present vascular BF information in real-time within the microscope’s eyepiece. Methods: The ability of SurgeON BFM to monitor BF status during reversible vascular occlusion procedures was investigated in two large animal models: occlusion of saphenous veins in six NZW rabbit hindlimbs and clipping of middle cerebral artery (MCA) branches in four Dorset sheep brain hemispheres. SurgeON BFM acquired, presented, and stored LSCI-based blood flow velocity index (BFVi) data and performed indocyanine green video angiography (ICG-VA) for corroboration. Results: Stored BFVi data were analyzed for each phase: pre-occlusion (baseline), with the vessel occluded (occlusion), and after reversal of occlusion (re-perfusion). In saphenous veins, BFVi relative to baseline reduced to 5.2±3.7 % during occlusion and returned to 102.9±14.9 % during re-perfusion. Unlike ICG-VA, SurgeON BFM was able to monitor reduced BFVi and characterize re-perfusion robustly during five serial occlusion procedures conducted 2–5 min apart on the same vessel. Across four sheep MCA vessels, BFVi reduced to 18.6±7.7 % and returned to 120.1±27.8 % of baseline during occlusion and re-perfusion phases, respectively. Conclusions: SurgeON BFM can noninvasively monitor vascular occlusion status and provide intuitive visualization of BF information in real-time to an operating surgeon. This technology may find application in vascular, plastic, and neurovascular surgery.

Umfang:: Online-Ressource

Fußnote:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Schlagworte:: blood flow imaging ; real-time feedback ; surgical technology ; noninvasive monitoring ; augmented reality visualization

ZLB-Systematik:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2405311537563.957208497356

Sammlung:: Medizin; Sonstiges

Copyright:: CC BY

Zugriffsberechtigung:: Freier Zugang

Volltext

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