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Title:: Open life sciences

Publication:: Berlin: De Gruyter

Note:: Gesehen am 15.04.15; Open Access; Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International

Scope:: Online-Ressource

ISSN:: 2391-5412

ZDB-ID:: 2817958-4

Keywords:: Zeitschrift

Classification:: Naturwissenschaften

DDC Group:: 570 Biowissenschaften, Biologie

Collection:: Naturwissenschaften

Copyright:: Rights reserved

Accessibility:: Free Access

Article

Author:: Huang, Yue; Su, Shuhua; Duan, Bo; Zhang, Yunfei; Xu, Zhengmin

Title:: Inhibition of mast cell activation by Jaranol-targeted Pirin ameliorates allergic responses in mouse allergic rhinitis

Publication:: Berlin: De Gruyter, 2025

Language:: English

Information:: Abstract: Jaranol, a bioactive compound derived from various traditional medicinal herbs, has demonstrated significant anti-inflammatory properties. This study investigates its effects and possible mechanisms underlying its anti-inflammatory role in mast cells, as well as ovalbumin (OVA)-induced allergic rhinitis (AR) mice model. Forty mice were randomly divided into blank, AR, dexamethasone (positive control), and Jaranol groups (10 mg/ml), with 10 mice in each group. Jaranol was found to inhibit nasal mucosal inflammation and reduce mast cell numbers in AR models. It also inhibited the secretion of several inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6, MCP-1, and CXCR10) from mast cells, as well as mast cell proliferation and migration. Interestingly, Pirin was differentially expressed in blank, AR, and Jaranol groups. Further studies indicated that Jaranol inhibited inflammatory cytokine secretion from mast cells by mediating Pirin and also inhibited mast cell proliferation and migration. Moreover, it inhibited mast cell function by suppressing Pirin expression. These findings suggest that Jaranol exerts its therapeutic effects by inhibiting Pirin expression in mast cells, thereby reducing inflammation and histopathological changes associated with AR.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Jaranol ; Kumatakenin ; allergic rhinitis ; Pirin

Classification:: Naturwissenschaften; Sonstiges

URN:: urn:nbn:de:101:1-2503290558560.739457518554

Collection:: Naturwissenschaften; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Metadata: Humoristische Rückblicke auf Berlins "gute alte" Zeit von 1834 bis 1864 / Wauer, Hugo (Public Domain)

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Metadata: Humoristische Rückblicke auf Berlins "gute alte" Zeit von 1834 bis 1864 / Wauer, Hugo (Public Domain) Access restriction There is no access restriction for this record. Copyright Public Domain Mark 1.0. You can find more information here.

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Metadata: Humoristische Rückblicke auf Berlins "gute alte" Zeit von 1834 bis 1864 / Wauer, Hugo (Public Domain)

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There is no access restriction for this record.

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Public Domain Mark 1.0. You can find more information here.