Open agriculture: Antidiabetic activity of methanolic extract of Hibiscus sabdariffa Linn. fruit in alloxan-induced Swiss albino diabetic mice

Akter, Shahida; Ali, Hanif; Shati, Ali A.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin I.; Sayyed, R. Z.; Yeasmin, Tanzima

Antidiabetic activity of methanolic extract of Hibiscus sabdariffa Linn. fruit in alloxan-induced Swiss albino diabetic mice / Akter, Shahida (CC BY)

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fullscreen : Antidiabetic activity of methanolic extract of Hibiscus sabdariffa Linn. fruit in alloxan-induced Swiss albino diabetic mice / Akter, Shahida (CC BY)

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CC BY: Attribution 4.0 International. You can find more information here.

Periodical

Title:: Open agriculture

Publication:: Warsaw: de Gruyter Open

Note:: Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2391-9531

ZDB-ID:: 2864636-8

VÖBB-Katalog:: 35262027

Keywords:: Zeitschrift

Classification:: Landwirtschaft

DDC Group:: 630 Landwirtschaft, Veterinärmedizin

Collection:: Landwirtschaft

Copyright:: Rights reserved

Accessibility:: Free Access

Title:: Open agriculture

Publication:: Warsaw: de Gruyter Open

Note:: Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2391-9531

ZDB-ID:: 2864636-8

VÖBB-Katalog:: 35262027

Keywords:: Zeitschrift

Classification:: Landwirtschaft

DDC Group:: 630 Landwirtschaft, Veterinärmedizin

Collection:: Landwirtschaft

Copyright:: Rights reserved

Accessibility:: Free Access

Article

Author:: Akter, Shahida; Ali, Hanif; Shati, Ali A.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin I.; Sayyed, R. Z.; Yeasmin, Tanzima

Title:: Antidiabetic activity of methanolic extract of Hibiscus sabdariffa Linn. fruit in alloxan-induced Swiss albino diabetic mice

Publication:: Warsaw: de Gruyter Open, 2024

Language:: English

Information:: Abstract: The majority of natural diabetic medications come from fruits and vegetables. These natural medications help protect humans from negative impacts of chemical antidiabetics by scavenging free radicals. The present study aimed to explore the antioxidant and antidiabetic properties of methanolic extract of fruits of Hibiscus sabdariffa Linn. (MEHSF) in alloxan-induced Swiss albino diabetic mice. The dried coarse powder of Hibiscus sabdariffa Linn. fruits was subjected to methanol extraction. The antidiabetic activity was determined by using alloxan-induced (80 mg/kg body weight) diabetic mice. Following a 15-day treatment period, serum biochemical parameters including total cholesterol (TC), triglyceride (TAG), LDL-cholesterol (LDL), HDL-cholesterol (HDL), serum glutamic pyruvic transaminase (SGPT), and serum glutamic-oxaloacetic transaminase (SGOT) enzymes were estimated. The antioxidant activity was evaluated through a DPPH and ABTS free radical scavenging assay. Total phenolic content and total flavonoid content were assessed using established methods. MESHF, containing polyphenolic and flavonoid compounds, exhibited antioxidant properties. A 100 and 200 mg/kg significantly (p < 0.05) lowered the blood glucose levels and improved biochemical parameters such as TC, TAG, LDL, and HDL in diabetic mice. Further, MESHF significantly (p < 0.05) reduced the activity of the SGPT and SGOT in diabetic mice compared to untreated diabetic mice. These results suggest that MEHSF with promising antioxidant and antidiabetic potentials can be considered to be a probable new resource of the antidiabetic agent.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Hibiscus sabdariffa fruit ; antioxidant activity ; antidiabetic activity ; alloxan ; lipid profile

Classification:: Landwirtschaft; Sonstiges

URN:: urn:nbn:de:101:1-2024021613021419895691

Collection:: Landwirtschaft; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Author:: Akter, Shahida; Ali, Hanif; Shati, Ali A.; Alfaifi, Mohammad Y.; Elbehairi, Serag Eldin I.; Sayyed, R. Z.; Yeasmin, Tanzima

Title:: Antidiabetic activity of methanolic extract of Hibiscus sabdariffa Linn. fruit in alloxan-induced Swiss albino diabetic mice

Publication:: Warsaw: de Gruyter Open, 2024

Language:: English

Information:: Abstract: The majority of natural diabetic medications come from fruits and vegetables. These natural medications help protect humans from negative impacts of chemical antidiabetics by scavenging free radicals. The present study aimed to explore the antioxidant and antidiabetic properties of methanolic extract of fruits of Hibiscus sabdariffa Linn. (MEHSF) in alloxan-induced Swiss albino diabetic mice. The dried coarse powder of Hibiscus sabdariffa Linn. fruits was subjected to methanol extraction. The antidiabetic activity was determined by using alloxan-induced (80 mg/kg body weight) diabetic mice. Following a 15-day treatment period, serum biochemical parameters including total cholesterol (TC), triglyceride (TAG), LDL-cholesterol (LDL), HDL-cholesterol (HDL), serum glutamic pyruvic transaminase (SGPT), and serum glutamic-oxaloacetic transaminase (SGOT) enzymes were estimated. The antioxidant activity was evaluated through a DPPH and ABTS free radical scavenging assay. Total phenolic content and total flavonoid content were assessed using established methods. MESHF, containing polyphenolic and flavonoid compounds, exhibited antioxidant properties. A 100 and 200 mg/kg significantly (p < 0.05) lowered the blood glucose levels and improved biochemical parameters such as TC, TAG, LDL, and HDL in diabetic mice. Further, MESHF significantly (p < 0.05) reduced the activity of the SGPT and SGOT in diabetic mice compared to untreated diabetic mice. These results suggest that MEHSF with promising antioxidant and antidiabetic potentials can be considered to be a probable new resource of the antidiabetic agent.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Hibiscus sabdariffa fruit ; antioxidant activity ; antidiabetic activity ; alloxan ; lipid profile

Classification:: Landwirtschaft; Sonstiges

URN:: urn:nbn:de:101:1-2024021613021419895691

Collection:: Landwirtschaft; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

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