Open chemistry: Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes

Hudiyanti, Dwi; Hidayati, Salma Nur; Siahaan, Parsaoran; Ngadiwiyana, Ngadiwiyana; Nur, Abidin; Sari, Ratna Indria; Amalia, Indrian Rizka; Christa, Sherllyn Meida; Patrechia, Amanda Chindy; Maharani, Adinda Eka

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Title:: Open chemistry

Publication:: Berlin: de Gruyter

Note:: Gesehen am 23.06.15; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2391-5420

ZDB-ID:: 2825411-9

VÖBB-Katalog:: 35314079

Previous Title:: Central European journal of chemistry

Keywords:: Zeitschrift

Classification:: Naturwissenschaften

Collection:: Naturwissenschaften

Copyright:: Rights reserved

Accessibility:: Free Access

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Author:: Hudiyanti, Dwi; Hidayati, Salma Nur; Siahaan, Parsaoran; Ngadiwiyana, Ngadiwiyana; Nur, Abidin; Sari, Ratna Indria; Amalia, Indrian Rizka; Christa, Sherllyn Meida; Patrechia, Amanda Chindy; Maharani, Adinda Eka

Title:: Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes

Publication:: Berlin: de Gruyter, 2025

Language:: English

Information:: Abstract: Vitamin E acetate (VEA) is commonly used in manufacturing pharmaceuticals, food additives, and animal feeds. However, VEA possesses disadvantages, including low water solubility, low bioavailability, and susceptibility to degradation and oxidation. This study investigated the use of cocoliposomes for encapsulating VEA (VEACL). The cocoliposomes consisted of coconut phospholipids (CocoPLs) and cholesterol (Chol). Several parameters, such as functional groups, transition temperature, encapsulation efficiency (EE), release profile, particle size, polydispersity index, and zeta potential, were analyzed to evaluate the impact of cholesterol inclusion on the cocoliposome membrane. The results show that the Fourier transform infrared spectra of VEACL do not exhibit any new, distinct peaks that differ from the peaks of its constituent composition. Therefore, it confirmed that no chemical reactions occurred during the manufacturing of VEACL. Cholesterol in the system raises the transition temperature of phospholipids and enhances the stability of VEACL. The EE remains above 80% despite a 20% increase in cholesterol levels. The release rate of VEA from cocoliposomes was slower with VEACL–20%Chol compared to VEACL–0%Chol. The cholesterol level leads to a decrease in particle size and an increase in the negative zeta potential of the cocoliposomes. Data show that cocoliposomes are effective carriers for VEA encapsulation.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: encapsulation efficiency ; differential scanning calorimeter ; release rate ; particle size ; zeta potential ; thermal analysis

Classification:: Naturwissenschaften; Sonstiges

URN:: urn:nbn:de:101:1-2501041716475.880053508996

Collection:: Naturwissenschaften; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

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fullscreen: Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes / Hudiyanti, Dwi (CC BY) Access restriction There is no access restriction for this record. Copyright CC BY: Attribution 4.0 International. You can find more information here.

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fullscreen: Impact of cholesterol in encapsulated vitamin E acetate within cocoliposomes / Hudiyanti, Dwi (CC BY)

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CC BY: Attribution 4.0 International. You can find more information here.