NeuroImmune Pharmacology and Therapeutics: Papaverine enhances autophagy, synaptic function, and memory in a mouse model of chronic REM sleep deprivation

Bhat, Abid R.; Bishir, Muhammed; Kalyan, Manjunath; Torterolo, Pablo; Chang, Sulie L.; Pandi-Perumal, Seithikurippu R.; Chidambaram, Saravana B.

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fullscreen: Papaverine enhances autophagy, synaptic function, and memory in a mouse model of chronic REM sleep deprivation / Bhat, Abid R. (CC BY)

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Title:: NeuroImmune Pharmacology and Therapeutics

Publication:: Berlin: De Gruyter

Note:: Gesehen am 3. Juni 2022; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2750-6665

ZDB-ID:: 3107864-3

VÖBB-Katalog:: 35283945

Keywords:: Zeitschrift

Classification:: Medizin

Collection:: Medizin

Copyright:: Rights reserved

Accessibility:: Free Access

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Author:: Bhat, Abid R.; Bishir, Muhammed; Kalyan, Manjunath; Torterolo, Pablo; Chang, Sulie L.; Pandi-Perumal, Seithikurippu R.; Chidambaram, Saravana B.

Title:: Papaverine enhances autophagy, synaptic function, and memory in a mouse model of chronic REM sleep deprivation

Publication:: Berlin: De Gruyter, 2025

Language:: English

Information:: Objectives: Cyclic nucleotides play a pivotal role in the establishment of synaptic plasticity which in turn facilitates the memory processes. Dysregulation of cyclic nucleotides due to increased phosphodiesterase (PDE) activity has been implicated in various neurodegenerative diseases. In this study, we investigated the potential effects of Papaverine (PAP), a PDE10A inhibitor, on cognitive dysfunction induced by chronic REM sleep deprivation in a mouse model. Methods: The modified multiple platform method (MMPM) was used for the induction of chronic REM sleep deprivation. Morris water maze was used to access the cognitive functions, while cAMP level was quantified by ELISA technique. Through Western blot analysis, we evaluated the expression of PDE10A, amyloid beta, CREB, BDNF, NR2A, NR2B, Beclin-1, LC3B, and synaptic proteins. Results: Administration of PAP ameliorated learning and memory deficits in mice subjected to chronic REM sleep deprivation. PAP increased cAMP and PSD-95, Synapsin, SAP97, pCREB, BDNF levels and decreased NR2A, and NR2B expression, along with the restoration of basal autophagy (Beclin-1, LC3B) in the hippocampal region of chronic REM sleep deprived mice. Increased cAMP and autophagy proteins are probably linked to the decrease in PDE10A and amyloid beta expression, respectively. Conclusions: This study evidences that papaverine, a non-narcotic opium alkaloid and PDE10A inhibitor, can alleviate learning and memory impairments induced by chronic REM sleep deprivation.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: phosphodiesterase ; cAMP ; autophagy ; chronic sleep deprivation ; memory ; papaverine

Classification:: Medizin

URN:: urn:nbn:de:101:1-2511110244535.717982616271

Collection:: Medizin

Copyright:: CC BY

Accessibility:: Free Access

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fullscreen: Papaverine enhances autophagy, synaptic function, and memory in a mouse model of chronic REM sleep deprivation / Bhat, Abid R. (CC BY) Access restriction There is no access restriction for this record. Copyright CC BY: Attribution 4.0 International. You can find more information here.

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