Open life sciences: Inhibition of mast cell activation by Jaranol-targeted Pirin ameliorates allergic responses in mouse allergic rhinitis

Huang, Yue; Su, Shuhua; Duan, Bo; Zhang, Yunfei; Xu, Zhengmin

Inhibition of mast cell activation by Jaranol-targeted Pirin ameliorates allergic responses in mouse allergic rhinitis / Huang, Yue (CC BY)

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fullscreen: Inhibition of mast cell activation by Jaranol-targeted Pirin ameliorates allergic responses in mouse allergic rhinitis / Huang, Yue (CC BY)

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Freier Zugang: Das Werk ist uneingeschränkt verfügbar.

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CC BY: Namensnennung 4.0 International. Weitere Informationen finden Sie hier.

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Titel:: Open life sciences

Erschienen:: Berlin: De Gruyter

Fußnote:: Gesehen am 15.04.15; Open Access; Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International

Umfang:: Online-Ressource

ISSN:: 2391-5412

ZDB-ID:: 2817958-4

Schlagworte:: Zeitschrift

ZLB-Systematik:: Naturwissenschaften

Dewey-Dezimalklassifikation:: 570 Biowissenschaften, Biologie

Sammlung:: Naturwissenschaften

Copyright:: Rechte vorbehalten

Zugriffsberechtigung:: Freier Zugang

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Verfasser:: Huang, Yue; Su, Shuhua; Duan, Bo; Zhang, Yunfei; Xu, Zhengmin

Titel:: Inhibition of mast cell activation by Jaranol-targeted Pirin ameliorates allergic responses in mouse allergic rhinitis

Erschienen:: Berlin: De Gruyter, 2025

Sprache:: Englisch

Zusammenfassung:: Abstract: Jaranol, a bioactive compound derived from various traditional medicinal herbs, has demonstrated significant anti-inflammatory properties. This study investigates its effects and possible mechanisms underlying its anti-inflammatory role in mast cells, as well as ovalbumin (OVA)-induced allergic rhinitis (AR) mice model. Forty mice were randomly divided into blank, AR, dexamethasone (positive control), and Jaranol groups (10 mg/ml), with 10 mice in each group. Jaranol was found to inhibit nasal mucosal inflammation and reduce mast cell numbers in AR models. It also inhibited the secretion of several inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6, MCP-1, and CXCR10) from mast cells, as well as mast cell proliferation and migration. Interestingly, Pirin was differentially expressed in blank, AR, and Jaranol groups. Further studies indicated that Jaranol inhibited inflammatory cytokine secretion from mast cells by mediating Pirin and also inhibited mast cell proliferation and migration. Moreover, it inhibited mast cell function by suppressing Pirin expression. These findings suggest that Jaranol exerts its therapeutic effects by inhibiting Pirin expression in mast cells, thereby reducing inflammation and histopathological changes associated with AR.

Umfang:: Online-Ressource

Fußnote:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Schlagworte:: Jaranol ; Kumatakenin ; allergic rhinitis ; Pirin

ZLB-Systematik:: Naturwissenschaften; Sonstiges

URN:: urn:nbn:de:101:1-2503290558560.739457518554

Sammlung:: Naturwissenschaften; Sonstiges

Copyright:: CC BY

Zugriffsberechtigung:: Freier Zugang

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