NeuroImmune Pharmacology and Therapeutics: Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice

Mondal, Susanta; Prieto, Shelby; Rangasamy, Suresh B.; Dutta, Debashis; Pahan, Kalipada

Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice / Mondal, Susanta (CC BY)

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fullscreen : Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice / Mondal, Susanta (CC BY)

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Periodical

Title:: NeuroImmune Pharmacology and Therapeutics

Publication:: Berlin: De Gruyter

Note:: Gesehen am 3. Juni 2022; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2750-6665

ZDB-ID:: 3107864-3

VÖBB-Katalog:: 35283945

Keywords:: Zeitschrift

Classification:: Medizin

Collection:: Medizin

Copyright:: Rights reserved

Accessibility:: Free Access

Title:: NeuroImmune Pharmacology and Therapeutics

Publication:: Berlin: De Gruyter

Note:: Gesehen am 3. Juni 2022; Open Access; Namensnennung 4.0 International

Scope:: Online-Ressource

ISSN:: 2750-6665

ZDB-ID:: 3107864-3

VÖBB-Katalog:: 35283945

Keywords:: Zeitschrift

Classification:: Medizin

Collection:: Medizin

Copyright:: Rights reserved

Accessibility:: Free Access

Article

Author:: Mondal, Susanta; Prieto, Shelby; Rangasamy, Suresh B.; Dutta, Debashis; Pahan, Kalipada

Title:: Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice

Publication:: Berlin: De Gruyter, 2024

Language:: English

Information:: Abstract: Huntington Disease (HD), a devastating hereditary neurodegenerative disorder, is caused by expanded CAG trinucleotide repeats in the huntingtin gene (Htt) on chromosome 4. Currently, there is no effective therapy for HD. Although aspirin, acetylsalicylic acid, is one of the most widely-used analgesics throughout the world, it has some side effects. Even at low doses, oral aspirin can cause gastrointestinal symptoms, such as heartburn, upset stomach, or pain. Therefore, to bypass the direct exposure of aspirin to stomach, here, we described a new mode of use of aspirin and demonstrated that nebulization of low-dose of aspirin (10 μg/mouse/d=0.4 mg/kg body wt/d roughly equivalent to 28 mg/adult human/d) alleviated HD pathology in N171-82Q transgenic mice. Our immunohistochemical and western blot studies showed that daily aspirin nebulization significantly reduced glial activation, inflammation and huntingtin pathology in striatum and cortex of N171-82Q mice. Aspirin nebulization also protected transgenic mice from brain volume shrinkage and improved general motor behaviors. Collectively, these results highlight that nebulization of low-dose aspirin may have therapeutic potential in the treatment of HD.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Huntington’s disease ; aspirin ; huntingtin pathology ; glial inflammation ; neuroprotection

Classification:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2024032514352406277814

Collection:: Medizin; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

Author:: Mondal, Susanta; Prieto, Shelby; Rangasamy, Suresh B.; Dutta, Debashis; Pahan, Kalipada

Title:: Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice

Publication:: Berlin: De Gruyter, 2024

Language:: English

Information:: Abstract: Huntington Disease (HD), a devastating hereditary neurodegenerative disorder, is caused by expanded CAG trinucleotide repeats in the huntingtin gene (Htt) on chromosome 4. Currently, there is no effective therapy for HD. Although aspirin, acetylsalicylic acid, is one of the most widely-used analgesics throughout the world, it has some side effects. Even at low doses, oral aspirin can cause gastrointestinal symptoms, such as heartburn, upset stomach, or pain. Therefore, to bypass the direct exposure of aspirin to stomach, here, we described a new mode of use of aspirin and demonstrated that nebulization of low-dose of aspirin (10 μg/mouse/d=0.4 mg/kg body wt/d roughly equivalent to 28 mg/adult human/d) alleviated HD pathology in N171-82Q transgenic mice. Our immunohistochemical and western blot studies showed that daily aspirin nebulization significantly reduced glial activation, inflammation and huntingtin pathology in striatum and cortex of N171-82Q mice. Aspirin nebulization also protected transgenic mice from brain volume shrinkage and improved general motor behaviors. Collectively, these results highlight that nebulization of low-dose aspirin may have therapeutic potential in the treatment of HD.

Scope:: Online-Ressource

Note:: Open Access; Archivierung/Langzeitarchivierung gewährleistet

Keywords:: Huntington’s disease ; aspirin ; huntingtin pathology ; glial inflammation ; neuroprotection

Classification:: Medizin; Sonstiges

URN:: urn:nbn:de:101:1-2024032514352406277814

Collection:: Medizin; Sonstiges

Copyright:: CC BY

Accessibility:: Free Access

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fullscreen : Nebulization of low-dose aspirin ameliorates Huntington’s pathology in N171-82Q transgenic mice / Mondal, Susanta (CC BY)

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